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Such loss deprives the body Post Date: Sat, 18 Oct 2008 15:02:34 +0000 Osteomalacia. The loss of calcium in stools (due to malabsorption) or the loss from body fluids by way of the kidney (essential hypercalciuria or renal tubular acidosis with augmented calcium excretion) promotes a negative balance of calcium. Such loss deprives the body of calcium stores, and the plasma calcium concentration falls slightly. Autor of the post: Undefined In this disorder, there Post Date: Sat, 18 Oct 2008 14:46:51 +0000 This, in turn, stimulates the secretion of parathyroid hormone, which restores the calcium concentration to normal but tends to promote some depression of plasma phosphorus.Osteitis Fibrosa Cystica. In this disorder, there is a primary increase in the secretion of parathyroid hormone that is usually accompanied by an increase in plasma calcium, some reduction of plasma phos-phorus, and a decreased renal tubular reabsorption of phosphate. Autor of the post: Undefined The sequence of events probably Post Date: Sat, 18 Oct 2008 14:28:15 +0000 Secondary Hyperparathyroidism. This condition may be seen in patients with chronic renal insuffi-ciency. The sequence of events probably starts with a high plasma concentration of phosphorus and a low value for calcium; this situation stimulates para-thyroid secretion. Autor of the post: Undefined Hypoparathyroidism Post Date: Sat, 18 Oct 2008 14:15:13 +0000 Since the elevated plasma phos-phorus is a consequence of renal insufficiency, it persists. The continuing hyperphosphatemia may be modified by the administration of aluminum hy-droxide gel, which tends to inhibit the absorption of phosphate from the bowel, owing to the formation of insoluble aluminum phosphates.Hypoparathyroidism. Autor of the post: Undefined IODIDEThere are numerous iodine-containing compounds Post Date: Sat, 18 Oct 2008 14:00:18 +0000 In this disorder, charac-terized by deficient parathyroid secretion, there is a rise in plasma phosphorus and a depressed concen-tration of calcium. This condition can be readily treated with vitamin D.IODIDEThere are numerous iodine-containing compounds of pharmacological interest. Autor of the post: Undefined Consequently, the pharmacology of iodine Post Date: Sat, 18 Oct 2008 13:50:09 +0000 These include elemental iodine, substances yielding elemental iodine, the inorganic iodides, and iodine-containing organic compounds. Iodine compounds have many unrelated actions and are used in a variety of ways. Consequently, the pharmacology of iodine has been largely subdivided with primary regard to therapeutic applications. Autor of the post: Undefined Absorption, Distribution, and Excretion Post Date: Sat, 18 Oct 2008 13:30:51 +0000 The antiseptic action of iodine is discussed in Chapter 50, while iodine and the thyroid gland are considered in Chapter 67. In this section, discussion will be limited primarily to the general pharmacological aspects of the iodides, their toxicology, and the use ofiodine-containing organic compounds in ra-diography.Absorption, Distribution, and Excretion. Autor of the post: Undefined These non-dietary sources may afford Post Date: Sat, 18 Oct 2008 13:14:09 +0000 In geographical areas where the iodine supply is adequate, the adult ingests about 150 jug per day. In addition to normal dietary sources of iodine, there are numerous incidental sources such as iodine-containing medicaments, iodine-containing radiographic contrast media, and table salt to which potassium iodide has been added. These non-dietary sources may afford confusion in the interpretation of certain laboratory tests employed in the diagnosis of thyroid disorders. Autor of the post: Undefined Intestinal malabsorption, for example Post Date: Sat, 18 Oct 2008 13:03:06 +0000 Elemental iodine is reduced to iodide in the gastrointestinal lumen, and absorption of iodide has been demonstrated throughout the gastrointestinal tract. Iodide is also absorbed from the enteric tract in the form of iodi-nated amino acids. Intestinal malabsorption, for example, in protein-calorie malnutrition, has been shown to result in decreased absorption of iodide (Ingenbleek and Beckers, 1973). Autor of the post: Undefined There are several reasons for Post Date: Sat, 18 Oct 2008 12:43:58 +0000 Iodide is distributed similarly to the chloride ion, largely extracellularly. However, the volume of distribution is larger than the ex-tracellular space. There are several reasons for a larger distribution. 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