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These com-pounds were introduced into Post Date: Sat, 18 Oct 2008 7:32:57 +0000 Tincture and solution of iodine, and iodophors used as antiseptics, are discussed in Chapter 50.Organic Compounds Yielding Iodide. These com-pounds were introduced into therapy because of their sustained action. Autor of the post: Undefined Such compounds are of little Post Date: Sat, 18 Oct 2008 7:20:23 +0000 They are slowly excreted, and during their sojourn in the body iodide is liberated. Most of the preparations consist of iodized proteins, oils, or fatty acids, or simpler iodine-containing compounds. Such compounds are of little therapeutic value in countries where dietary supplements are used. Autor of the post: Undefined Two types of iodinated organic Post Date: Sat, 18 Oct 2008 7:06:54 +0000 Some, however, are useful to prevent endemic goiter in underdeveloped areas.Iodine-Containing Organic Compounds for Radi-ographic Use. Two types of iodinated organic com-pounds are employed in radiography: the lipid-soluble and the water-soluble agents. Autor of the post: Undefined After inges-tion, it is absorbed Post Date: Sat, 18 Oct 2008 6:56:41 +0000 The following preparations are among those available.Iopanoic Acid, USP (TELEPAQUE), is employed as a contrast medium in cholecystography. After inges-tion, it is absorbed promptly, undergoes conjugation with glucuronic acid in the liver, is concentrated and stored in the gallbladder, and is eliminated in the bile. Autor of the post: Undefined Iophendylate Injection, USP (PANTOPAQUE) Post Date: Sat, 18 Oct 2008 6:39:21 +0000 Iopanoic acid seldom causes undesirable reac-tions and has a low toxicity. However, its use is contraindicated in acute glomerulonephritis, severe chronic renal insufficiency, and acute disorders of the gastrointestinal tract.Iophendylate Injection, USP (PANTOPAQUE), is a mixture of isomers of ethyl iodophenylundecylate. Autor of the post: Undefined It is equally useful for Post Date: Sat, 18 Oct 2008 6:28:17 +0000 It is an absorbable, iodized fatty acid compound of low viscosity designed especially for myelography. This agent should not be used intravascularly. It is equally useful for visualization of all regions of the spinal cord, although this may be technically more difficult in the cervical and thoracic regions. Autor of the post: Undefined The agent should not Post Date: Sat, 18 Oct 2008 6:17:28 +0000 When examination is completed, the compound should be removed by aspiration. When the bulk of the mate-rial is removed, the remainder is absorbed within a few months and the incidence of side reactions is low. The agent should not be used when lumbar puncture is contraindicated; and, to avoid subdural and extra-arachnoid extravasation, it should not be employed within 10 days of a previous lumbar puncture. Autor of the post: Undefined The oral preparations are used Post Date: Sat, 18 Oct 2008 5:57:52 +0000 Iophendylate also is used in emulsified aqueous form as a contrast medium for visualization of the biliary tree, sinus tracts, and certain body cavities.Diatrizoate Sodium Injection, USP, and Dia-trizoate Sodium Oral Solution, USP (HYPAQUE), are perhaps the least toxic of radiopaque media. The oral preparations are used for roentgenographic ex-amination of the gastrointestinal tract. Autor of the post: Undefined Diatrizoate Meglumine Injection, USP, and dia-trizoate Post Date: Sat, 18 Oct 2008 5:41:41 +0000 Preparations for intravenous use are available in several formula-tions with different iodine contents and are used for a wide variety of roentgenographic procedures. After intravenous administration, diatrizoate sodium is excreted unchanged by the kidney.Diatrizoate Meglumine Injection, USP, and dia-trizoate meglumine oral solution (CARDIOGRAFIN, GASTROGRAFIN, RENO-M) have the same actions as diatrizoate sodium. Autor of the post: Undefined Various mixtures of diatrizoate meglumine Post Date: Sat, 18 Oct 2008 5:28:50 +0000 They are used for examination of the gastrointestinal tract, angiography, and intra-venous urography. The dosages vary depending upon the route of administration as well as the typeof examination to be undertaken. Various mixtures of diatrizoate meglumine and diatrizoate sodium are also marketed for intravenous use. 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