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Unlike other diuretics, triamterene does Post Date: Tue, 14 Oct 2008 11:46:43 +0000 It is the latter that is normally the driving force for potassium secretion (Gatzy, 1971). The slight effect onurinary acidification is also probably distal Under some circumstances, triamterene may be slightly uricosuric, but the mechanism of this action has not been examined. Unlike other diuretics, triamterene does not appear to cause urate retention. Autor of the post: Undefined The most common are nausea Post Date: Tue, 14 Oct 2008 11:32:21 +0000 Clinical Toxicity. Triamterene produces relatively few side effects. The most common are nausea, vomiting, leg cramps, and dizzi-ness. Autor of the post: Undefined Preparations Post Date: Tue, 14 Oct 2008 11:16:02 +0000 Slight-to-moderate azotemia is rela-tively common. This does not appear to be directly related to electrolyte and water im-balance and is reversible.Preparations. Autor of the post: Undefined The usual initial dose Post Date: Tue, 14 Oct 2008 11:04:33 +0000 Triamterene, USP (DYRENIUM), is administered only by the oral route. It is marketed in capsules containing 100 mg. The usual initial dose is 100 mg, given twice daily. Autor of the post: Undefined Therapeutic Uses Post Date: Tue, 14 Oct 2008 10:53:27 +0000 The maximal dose is 300 mg. The maintenance dose should be determined for the individual patient and may be as low as 100 mg every other day.Therapeutic Uses. Autor of the post: Undefined In general, the administration Post Date: Tue, 14 Oct 2008 10:40:14 +0000 Some patients with edema have a satisfactory diuretic response to triamterene alone. However, the available clinical data suggest that the greatest usefulness of this drug may be in conjunction with other diuretic agents. In general, the administration of triamterene with another natriuretic compound augments natriuresis and re-duces potassium loss. Autor of the post: Undefined Hansen and Bender (1967) summarized Post Date: Tue, 14 Oct 2008 10:24:45 +0000 With concurrent drug therapy, it is this latter effect that is more consistently ob-served. Therefore, the rationale of concomitant drug therapy is primarily in relation to potassium metab-olism. Hansen and Bender (1967) summarized the experience obtained from several hundred patients maintained on long-term regimens with triamterene alone, chlorothiazide alone, and both drugs together, and showed that both drugs together provided the highest incidence of normal plasma potassium values. Autor of the post: Undefined Pharmacological Actions Post Date: Tue, 14 Oct 2008 10:12:15 +0000 Because of the real possibility of inducing serious hyperkalemia, patients treated with triamter-ene should not receive supplements of potassium.AMILORIDEAmiloride is an organic base with the following structural formula:istration, the action of amiloride on the kidney reaches a peak within about 6 hours and usually ceases within 24 hours.Pharmacological Actions. Autor of the post: Undefined At the same time, there Post Date: Tue, 14 Oct 2008 9:54:18 +0000 In the usual dosage, amiloride has no important pharmacological actions except those related to the renal tubular transport of electrolytes. Under normal conditions, amiloride slightly increases the renal excretion of sodium and chloride without a significant change in the glomeru-lar filtration rate. At the same time, there may be a moderate increase in urinary pH, indicative of a lesser degree of hydrogen ion secretion. Autor of the post: Undefined Under these conditions, the effect Post Date: Tue, 14 Oct 2008 9:38:16 +0000 The finding of greatest interest is that, under all conditions tested, natriuresis is associated with either only a slight increase or sometimes an absolute decrease in potas-sium excretion. This effect of amiloride is undoubt-edly most striking when it is given together with more potent saluretic agents. Under these conditions, the effect of amiloride is approximately additive as far as sodium and chloride excretion is concerned, but it is antagonistic with respect to potassium. 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